Extubating extremely preterm infants: Predictors of success and outcomes following failure

Abstract

Objectives To identify variables that predict extubation success in extremely preterm infants born <28 weeks gestational age (GA), and to compare outcomes between those who had successful or failed extubation. Study design A secondary analysis of data from a randomized trial of postextubation respiratory support that included 174 extremely preterm infants. "Extubation success" was defined as not requiring reintubation within 7 days, and "extubation failure" the converse. Predictive variables that were different between groups were included in a multivariable logistic regression model. Results Sixty-eight percent of infants were successfully extubated. Compared with those infants who had extu..